The differentials for eccrine porocarcinoma are basal cell carcinoma, squamous cell carcinoma, amelanotic melanoma and metastatic adenocarcinoma. They affect the eccrine sweat glands, which are the major sweat glands of the body. A diagnosis of eccrine poroma was made based on these characteristic histologic features. A preexisting benign eccrine poroma was identified in one case only. To my knowledge, such a linear distribution of multiple eccrine poromas has not been reported in the dermatologic literature. Mar 19, 2018 eccrine porocarcinomas eps are rare malignant tumours of the intraepidermic sweat gland duct and most often arise from benign eccrine poromas.
Eccrine poroma is an adnexal neoplasm originating from the acrosyringium, the intraepidermal portion of the sweat gland duct. Radiation oncologyporocarcinoma wikibooks, open books. Cd23 expression was detected in all benign apocrine tumors and in half of benign eccrine tumors, particularly those derived. However, eccrine poroma is benign in nature, whilst eccrine porocarcinoma is regarded as its.
One patient had an amputation of the index finger fig 5a,b. Eccrine porocarcinoma an overview sciencedirect topics. Apocrine eccrine carcinomas are rare and associated with poor prognosis. Eccrine poromas mainly involve the nonhairy surfaces of the skin, however, have also been found on hair bearing areas. Eccrine poroma is a benign sweat gland tumor arising from the cells differentiating towards the intraepidermal ductal portion of eccrine sweat duct 1.
Dec, 2016 eccrine porocarcinoma is a rare type of skin cancer that may occur by chance or may develop from a benign noncancerous skin tumor. Cases that are marked with an asterisk are part of the 200 must know cases for dermatology boards. However, studies on genetic alterations and egfr and her2 status of apocrine eccrine carcinomas are few in number. Eccrine porocarcinoma genetic and rare diseases information. We describe two respective cases of benign and malignant eccrine poroma on. All of the neoplasms were histologically identical to eccrine poroma juxtaepidermal acrospiroma, a common benign neoplasm in humans that originates from the acrosyringium and upper dermal duct of eccrine glands. Treatment of eccrine porocarcinoma with metastasis to the. Intraepidermal macrophages as mimics of pagetoid lesions dr. Eccrine poroma definition of eccrine poroma by medical. Sodium pentobarbitone or chloralose anaesthesia were used. The histological sections presented are offered as evidence of the eclectic nature of eccrine poroma. Effective for cases diagnosed january 1, 2015 and later.
A recent article by roach 1 described a partial response to isotretinoin in a patient with metastatic malignant eccrine poroma. The presentation of eccrine poroma after trauma or radiation exposure has been documented in the literature. Request pdf pigmented eccrine porocarcinoma eccrine porocarcinoma is a rare cutaneous neoplasm arising from the eccrine sweat duct. Click add files and select the files you want to include in your pdf. Whole genome and whole transcriptome genomic profiling of a. Poromas are uncommon, benign sweat gland tumors that are clinically and dermoscopically challenging to diagnose. The cell has a cuboidal appearance with a uniform basophilic nucleus, and intercellular bridges. There was no previous history of trauma to the area.
It is interesting that in this study we detected mutations in pik3ca and tp53 in a subset of apocrine eccrine carcinomas, a therapeuticallyrelevant finding since both of these genes are known to be frequently mutated in breast carcinomas. This is apparently the first recording of eccrine poromatosis. Pdf on jul 1, 2015, vaishali wankhade and others published eccrine poroma find, read and cite all the research you need on researchgate. Tumour with only intraepidermal component is known as insitu porocarcinoma. Abstractthe eccrine poroma or hidracanthoma simplex is a rare benign adnexal tumor of ephitelial cells. Benign component of eccrine poroma or hydroacanthoma simplex may be seen in 10% cases. Pdf eccrine porocarcinoma is a rare carcinoma arising from the intraepidermal duct of eccrine sweat glands and constitute about 0.
Open access publication intraepidermal eccrine adenocarcinoma. This article is from annals of dermatology, volume 25. Eccrine poroma ep is a benign adnexal tumor derived from the. Eccrine porocarcinoma, also known as malignant eccrine poroma, is a rare malignancy of the eccrine sweat glands. A poroma is a benign tumor arising from the acrosyringium the intraepidermal part of a sweat gland duct. The tumor mass extended to the cranial base around the right foramen ovale without any intracranial extension black arrow. It generally appears as a solitary, slow growing, sessile, pinktored and wellcircumscribed papule, plaque or nodule. Eccrine poromas ep derive from the intraepidermal portion of eccrine sweat ducts. Poromas were first described in 1956 by pinkus, goldman and login as tumors of the eccrine sweat glands, although there are reports of exocrine differentiation.
Clinicopathological analysis of 384 cases of poroid neoplasms. Eccrine poroma is a benign adnexal tumor arising from cells of the outer layer of the acrosyringium and upper dermal eccrine duct. Factors in the surgical management of primary eccrine porocarcinoma. This study describes the clinical and pathological findings in a series of 21 cases of epc showing extensive squamous differentiation. To the authors knowledge this is the first report documenting an eccrine poroma in a dog. Verrucous carcinoma northern ohio foot and ankle foundation.
One can usually observe a sharp line of demarcation between the adjacent epidermis and the tumor cells. Eccrine poroma is a rare benign adnexal tumor of epithelial cells originating from the terminal ductal portion of the sweat glands that is typically located on palms and soles, although other cutaneous sites can be affected 1. Actinic damage, trauma, radiation and the human papilloma virus hpv are believed to be involved. Key difference eccrine vs apocrine the skin is considered as the largest organ of the body that composes different structures including glands, blood vessels, nerve endings, hair follicles and three layers of dermis. In two patients, a lymph node dissection was performed at the time of. Composition of the secretion from the eccrine sweat glands of. These noncancerous growths take hold in eccrine sweat glands, are slow to form and can take years to make themselves known. Squamous differentiation in eccrine porocarcinoma epc is an unusual phenomenon that has rarely been reported in the literature. First described by pinkus et al1 in 1956, eccrine poroma is a benign neoplasm of cells from the intraepidermal ductal portion of the eccrine sweat gland.
There are 36 cases of complex poroid tumors with folliculosebaceous and apocrine differentiation reported in the literature. Aug 22, 2011 eccrine porocarcinoma is a rare malignancy of the eccrine sweat gland. Cutaneous eccrine porocarcinomas are uncommon malignant tumors of the sweat gland. Other poroid neoplasms pns, namely hidroacanthoma simplex hs, dermal duct tumor ddt, and poroid hidradenoma ph, are. A case of an eccrine poroma is described in a 77 yearold patient with a painful lesion on his right foot, with easy bleeding and limitation for deambulation. It is a benign neoplasm originating from the intraepidermal ductal portion of the eccrine sweat duct. Although poromas have traditionally been thought to originate. He noted that volume 23 number 4, part 1 october 1990 giant eccrine acrospiroma 667 fig. A poroma is a benign skin tumor derived from sweat glands. Skin biopsy of poroma shows a growth of terminal duct cells.
Eccrine poroma ep are relatively common benign eccrine neoplasms. The majority of eccrine poromas are found on areas with a high concentration of eccrine sweat glands. Intraepidermal eccrine poroma a histochemical and enzymelzistocliemical study karl hoisjbar, md, and klaus wolff, md an intraepidermal variant of eccrine poroma is described. The tumor, often consisting of broad anastamosing bands, arises from the epidermis and extends downward into the dermis. The aim of this brief report is to summarize the hitherto undescribed expression of keratin 20 in malignant eccrine poromas. Treatment fifteen tumours were surgically excised, 11 with tumourfree margins and four with positive surgical margins. Pdf eccrine porocarcinoma associated with an eccrine poroma.
Multiple eccrine poromas, or eccrine poromatosis, may occur in patients who have undergone radiotherapy andor polychemotherapy. Mehregan, md monroe, mich ordinarily it is not profitable to use single atypical cases for deductions of general nature. Besides surgical resection, little is known about the role of. Acrospiroma is a cutaneous condition, primarily occurring in adult women, that is a form of benign adnexal neoplasm closely related to poroma. Summary we present a 71 years old patient with a progressive growing lesion in the right buttock. How to merge pdfs and combine pdf files adobe acrobat dc. Eccrine porocarcinoma is a rare type of skin cancer that may occur by chance or may develop from a benign noncancerous skin tumor. Eccrine porocarcinoma ep, a particular malignant sweat gland tumor, represents only 0. We reported a case of eccrine poroma arising on the paranasal area, an unusual location for this condition. Specific subtypes are primarily defined by location of tumor, and include. Chemotherapeutic drugs that selectively target cancerpromoting pathways may complement conventional therapeutic approaches.
Eccrine poroma and porocarcinoma on the same unusual location. The epidermis shows long, thin projections, with confluent terminations and a. Cats pad sweat contains lactate, glucose is almost absent, and the sodium and chloride concentrations. Once you merge pdfs, you can send them directly to your email or download the file to our computer and view. The clinical picture is not diagnostic, resembling that of seborrhoeic warts or bowens disease. Pdf merge combine pdf files free tool to merge pdf online. However, it may be completely intraepidermal hidroacanthoma simplex, and, at times, appear to be completely dermal dermal duct tumor. It is usually located on the palms and soles but it may also develop on other locations. Eccrine poroma is a benign tumour of eccrine duct epithelium. Pdf poroma is a benign adnexal neoplasm of the terminal sweat gland duct. Eccrine carcinoma is a quite rare malignant tumor that typically arises from a normal sweat gland and that features a rather high recurrence rate subsequent to simple excision. The mf were irreg ularly distributed, and two of the neoplasms had ar eas with 10 to mf per 10 hpf. A malignant eccrine poroma responds to isotretinoin.
The authors evaluated 111 poroid tumors including 63 typical eccrine poromas and 48 poroid tumors with folliculosebaceous elements. Eccrine poroma frequently occurs as a solitary tumour, and only a few reports have described the occurrence of multiple lesions. Pdf eccrine porocarcinoma malignant eccrine poroma. Kenneth berean introduction pagetoid spread ps refers to the discrete intraepidermal proliferation of cells occurring singly or in nests at all levels of the epidermis. About 20% of epc will recur and about 20% will metastasize to regional lymph nodes. You may do so in any reasonable manner, but not in. Although the original term poroma was initially used to describe a tumor derived from the ductal epithelium of eccrine sweat glands, the term is used in general reference to tumors derived from ductal portions of both eccrine and apocrine sweat glands. Eccrine porocarcinoma presenting as a recurrent wart. It is usually found frequently on the lower extremities, and it affects both sexes equally usually in the sixth to seventh decade. Fewer than 300 cases have been reported in the literature, and it is believed to represent only 0. However, once in a while, a freak case illuminates a confused and debated field just because it presents singular and rule defying. Histopathologic diagnosis was consistent with eccrine poroma. You can merge pdfs or a mix of pdf documents and other files.
Eccrine poroma is a benign adnexal tumor that was first described by pinkus et al in 1956. Eccrine poroma primary care dermatology society uk. May arise from preexisting benign eccrine poroma, with increase in size, tenderness, and sometimes odor 300 cases reported in the literature. The following case documents an example of a pigmented eccrine poroma which occurred in an unusual location. Intraepidermal eccrine poroma a histochemical and enzyme. We describe a case of eccrine porocarcinoma with metastasis to the parotid gland with special emphasis on the role of surgical resection and adjuvant radiation therapy. Oct 09, 2012 apocrine eccrine carcinomas and breast carcinomas are analogous tumors often with similar histology. Click, drag, and drop to reorder files or press delete to remove any content you dont want. Porocarcinoma malignant poroma was first described by pinkus and mehregan as epidermotropic eccrine carcinoma. A 76yearold caucasian man presented to our hospital with a left temporal mass. Eccrine poroma is a circumscribed tumor composed of cords and broad columns of uniform basaloid cells extending into the dermis from the undersurface of the.
Linear eccrine poroma jama dermatology jama network. Eccrine porocarcinoma usually are found in adults older than 60 and appear as a single red elevated solid mass nodule or a thickened or elevated lesion plaque. Eccrine poroma, a tumor derived from the acrosyringium, presents as a solitary, pink or red exophytic nodule, usually on plantar or palmar skin. Eccrine poroma is a benign tumor that occurs in eccrine or apocrine sweat glands. The initial tumor was biopsied, excised and diagnosed as. Multiple eccrine poromas in the paw of a dog whitley. It is a finding most commonly seen in association with neoplasms, the majority of which are. The external surface shows a polypoidal growth measuring 4. An eccrine poroma wont usually harm you, but it can make you uncomfortable especially if it forms on the sole of your foot.
The leading primary care society for dermatology and skin surgery. We herein report three cases of poroma, which showed sebaceous differentiation. Eccrine porocarcinoma is the malignant phenotype arising from. Dermoscopic features associated with poroma include branched vessels with rounded endings, white interlacing areas around vessels, yellow structureless areas, and milkyred globules. A malignant eccrine poroma responds to isotretinoin cis retinoic acid mack roach iii, m.
Crockett, dpm2, donald kushner, dpm3 the foot and ankle online journal 2 7. Intraepidermal macrophages as mimics of pagetoid lesions. With this report, there have been two cases of invacarcinoma, and eccrine poroepithelioma. Poroid hidradenoma refers to a hybrid lesion with features of hidradenoma and poroma. Epidermotropic eccrine carcinoma a case combining features of eccrine poroma and pagets dermatosis hermann pinkus, md and amir h. Effective for cases diagnosed january 1, 2015 and later indiana state cancer registry indiana state department of health 2 north meridian street, section 6b. It is a solitary lesion, usually the same color as the skin and located on the. This is an uncommon, benign neoplasm with eccrine differentiation, socalled because it is a. Eccrine porocarcinoma is a rare malignancy of the eccrine sweat gland. In 1990, abenoza and ackerman put forward the addition of a fourth member to this poroma familyporoid hidradenoma 2.
Dermatopathology slide atlas they are stored as adobe pdf files and you will need a reader to access these. Poroid hidradenoma is an uncommon variant of the eccrine poroma described by abenoza and ackerman in 1990. To the authors knowledge this is the first report documenting an eccrine poroma. Hidradenoma or acrospiroma is a benign dermal growth closely related to poroma except without connection to the epidermis. Some are familialbut the causative gene is not known. Eccrine poroma along with hidroacanthoma simplex, dermal duct tumor, and poroid hidrad. Insights of its occurrence and differentials in the. Open access publication intraepidermal eccrine adenocarcinoma of the foot.
Verrucous carcinoma of the skin is an uncommon lowgrade squamous. Abstractan eccrine poroma is a benign neoplasm that originates from the intraepidermal ductal portion of. It is a common skin disorder predominantly found on the sole, but only three reports demonstrating enlargement during pregnancy have been documented. A painful step pendulating plantar eccrine poroma ncbi. Eccrine porocarcinoma epc, originally described by pinkus and mehregan 1 in 1963, is an exceedingly rare sweat gland tumor most commonly seen in older patients.
A case combining features of eccrine poroma and pagets dermatosis. In our case, we present a 42yearold male patient with a recurring exophytic tumor on the right lower extremity without local extension. The age of presentation varies from 28 to 77 years, with a. Eccrine poroma and porocarcinoma on the same unusual. Pinkus initially described eccrine poroma as a benign neoplasm of the acrosyringium. Giant eccrine hidradenoma mimicking a malignant tumor of the salivary gland.
Folliculosebaceous poroid tumors fspt had basaloid and squamous cells 100%, ducts with steatocystomalike cuticles and. The expression of cd23 in cutaneous nonlymphoid neoplasms. Tumors arising from skin appendages hair follicle origin trichoepithelioma, trichilemmoma, trichofolliculoma eccrine gland origin eccrine poroma, chondroid syringoma apocrine gland origin cylindroma sebaceous gland origin sebaceous adenoma, carcinoma usually benign, but malignant forms exist. Eccrine hidradenoma pdf eccrine hidradenoma is a rare benign cutaneous neoplasm, believed to arise from the distal excretory duct of the eccrine sweat glands. The patients were two men and one woman, and the involved sites were the thigh, head and back. Once files have been uploaded to our system, change the order of your pdf documents. In 1969, mishima sive eccrine porocarcinoma of the vulva. There is a mortality rate of 67% in patients with lymph node metastases. Pigmented eccrine poroma simulating malignant melanoma. Given its rather poor response to adjuvant therapy, wide excision of the lesion with tumorfree margins may offer a reasonable chance for longterm control of this neoplasm. Expression of keratin 20 in malignant eccrine poromas.
A case of eccrine poroma on the paranasal area koreamed. Dystrophic calcification is rarely found in lesions of eccrine poroma, and only 2 cases of eccrine poroma with calcification have been reported thus far. It is usually a solitary asymptomatic neoplasm that rarely becomes malignant in less than 1% of cases. The sweat composition from the cats foot pad was examined at various rates of secretion. This file is licensed under the creative commons attributionshare alike 3. Eccrine poroma is a benign neoplasm of the intraepidermal portion of the eccrine sweat duct. Pigmentation in the tumor cells is rare but has been mentioned in a few papers.
Mar 16, 2011 eccrine porocarcinoma epc is a rare type of skin cancer arising from the intraepidermal portion of eccrine sweat glands or acrosyringium, representing 0. Eccrine poroma was first reported by pinkus in 1956 and represents 10% of all sweat gland tumors. They are solitary, moist, exophytic bright red to flesh colored, painful, sessile or pedunculated papule or nodule usually occurring on palms or. A 65yearold white woman had more than 100 eccrine poromas on her palms and soles. Eccrine poromatosis associated with polychemotherapy. Malignant eccrine poroma and isotretinoin annals of.
Eccrine porocarcinoma epc was first described by mehregan and pinkus in 1963 on the ankle of an. Recently, cooper16 also observed that 25% of benign eccrine acrospiromas 9 of 36 showed more than 2 mf per hpf maximum 7. Pathology outlines hidradenoma eccrine acrospiroma. Rearrange individual pages or entire files in the desired order. Eccrine poroma is a relatively common benign cutaneous epithelial neoplasm with sweat duct differentiation, first reported by pinkus et al. Eccrine poroma is a benign adnexal tumour of the uppermost portion of the intraepidermal eccrine sweat gland duct and acrosyringium.
This report describes the case of an eccrine poroma. Sweat gland tumors have been classified according to their presumed physiological counterpart of the sweat apparatus. Intracranial extension of an eccrine porocarcinoma in. Immunohistochemical staining of cd23 was performed in a total of 1 cases of apocrine, eccrine, follicular and other cutaneous nonlymphoid tumors. David weedon ao md frcpa fcaphon, in weedons skin pathology third edition, 2010.
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